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The extraordinary story of the breakthrough discoveries in cell aging, stem cell research, and therapeutic cloning, and the tremendous promise they hold for dramatically extending human life.
Dr. Michael West has been consumed with the mystery of science since he was as an inquisitive child mixing chemicals in his attic-turned-laboratory. Today, he stands in the center of a controversy so great that the list of those lining up against him includes President George W. Bush.
Once a devoted creationist eager to dispel theories of human evolution, Dr. West was set on a quest to find a scientific solution to the devastating effects of disease and death after the death of his father. He became immersed in the study of cell aging and the discovery of the cellular “clock” telomerase – the mechanism that controls cell aging. His work led him to found the biotechnology company Geron, a pioneer in the field of stem cell research. His new company, Advanced Cell Technology, is the only organization in the United States pursuing human therapeutic cloning research – research in the field of “regenerative medicine” intended to repair damaged and diseased human organs and tissues.
Unlike reproductive cloning, the attempt to clone a human child, therapeutic cloning is a process of growing cells, using a patient’s own DNA that is inserted it into an unfertilized egg cell to create embryonic stem cells, cells that hold the promise of repairing the damage of age and disease – in essence, making the cell young again. The potential for therapeutic cloning to treat afflictions caused by the loss of dysfunction of cells – from spinal cord injury and skin burns to kidney failures and cancer – is enormous.
Part memoir, part adventure story, The Immortal Cell chronicles the breakthroughs Dr. West and other scientists have made in biotechnology over the past decade – and the astonishing potential they offer us to cure diseases and improve the quality of human life.
- Sales Rank: #185087 in Books
- Brand: Doubleday
- Published on: 2003-09-16
- Released on: 2003-09-16
- Original language: English
- Number of items: 1
- Dimensions: 8.55" h x .88" w x 5.77" l, .89 pounds
- Binding: Hardcover
- 256 pages
- Great product!
Amazon.com Review
Human beings have always hungered for immortality. But even in myths, those who find the secrets of eternal life often have to pay a high price. Michael West, CEO of Advanced Cell Technology, has spent most of his career as a biotechnologist seeking ways to make mammalian cells live forever. His successes put him at the center of political, moral, and religious firestorms. In The Immortal Cell, West offers not only a chronology of the emerging science of immortality, but a personal journal of his own path from strict creationist to ardent scientist seeking to shape human evolution. It was West and his cohorts who announced in 2001 that by inserting a person's own DNA into an unfertilized egg cell from a woman of reproductive age, they could create embryonic stem cells--cells that might be able to repair any number of problems for the DNA donor, including burns, cancer, degenerative disorders, and even normal aging. Accused of "playing God," West became one of the central figures in the debates on human cloning and was compared to Osama bin Laden by one histrionic news agent. In The Immortal Cell, West describes both the research and the furor that followed. Though the biology is a little tough for general readers, West does a fine job of using diagrams and step-by-step descriptions to explain his processes of cell culture and manipulation. The debate over therapeutic cloning of human cells is far from over, and readers seeking to better understand the debate will find West's book an unapologetic, one-sided argument in favor of human stem cell research. --Therese Littleton
From Publishers Weekly
West was once asked by a journalist: "Just what does it mean to play God?" The author, whose controversial career in therapeutic cloning has been chronicled extensively by the media, seeks to respond in a brisk memoir that describes a boy who sought answers to mortality in his Protestant faith and eventually took matters into his own hands as a scientist-entrepreneur. He describes his founding of Geron, the first biotech firm to seek a "cure" for human aging, and his decision to leave for his current venture, Advanced Cell Technology. He continues with the media firestorm surrounding ACT's crafting of stem cells from cloned embryos, which plays out under the shadow of President Bush's decision to curb stem-cell research, and finishes with the argument that to ban potential therapies before they are tested is to abort progress in medical research. Along the way, he gives a primer on cell theory, genomics and the basics of aging, but it's all drowned in the thin gruel of a campaign book. West glosses over his embattled departure from Geron in about two pages, citing his messianic calling to deny death, and gives the ACT controversy, one of the most interesting parts of the story, relatively short shrift. To get the full story, one would do better to pick up Stephen S. Hall's Merchants of Immortality, which fills in the holes left by West. West writes like the Big Money science pitchman he is-but many will agree with his position on the necessity for stem-cell research.
Copyright 2003 Reed Business Information, Inc.
From Booklist
The stem-cell debate was the hot science story of 2001, and West cut one of the higher media profiles among scientists conducting stem-cell research, work roundly condemned by Catholic and other churches for its manipulation of the human embryo. To West, this engineering is justified by the prospect that human tissue can be grown from stem cells, and his retort to ethical qualms is the standard argument that the embryo is not a human life. However one regards that assertion, the reader will obtain in this account of his career clear information about what West has done in the lab and in business to promote his biotechnology schemes. Passionately interested in finding the biological causes of aging, West reviews historical research on cell senescence; dramatizes his role in understanding telomeres, the tips of chromosomes believed to act as cellular "clocks"; and outlines the methods of introducing DNA into an embryo. Accessible to the lay reader, West's is a self-confident presentation from the pro-cloning side of the stem-cell controversy. Gilbert Taylor
Copyright � American Library Association. All rights reserved
Most helpful customer reviews
6 of 12 people found the following review helpful.
Tinkering with the atom - now tinkering with human DNA...
By M. Franta
Dr. Michael West is a brilliant man in search of high tech ways to cure catastrophic diseases & pathologies - such as type I Diabetes, Quadriplegia, cancer and heart damage from heart attacks. All noble quests to benefit mankind. The only problem with this is that along with the potential to help mankind with regenerative medicine concepts, therein lies another darker potential. The corruptability of such an endeaver, and yes, there are always those equally brilliant scientists out there who are willing to tweak the bad that generates from the good.
West goes into vague detail explaining what stem cells are, and what the science can acheive in medicine, and cloning. I wish he went into further depth giving examples and photos of what he witnessed under the microscope. If he would have included some slides, I would have given the book a 5 star rating instead of the 4. It is a good book that gives readers a taste of this controversial topic. He further explains how Dolly the sheep came to be in this world, and yes, the sheep was named after Dolly Parton, the country singer, because the sheep was cloned out of a cell from the breast tissue of another sheep.
All this research into the mortal cell costs millions, perhaps billions of dollars, $$$, but in the end, the goal is not to prolong life forever. It's really to maintain the quality of life for all, especially the aged. Dr. West is very compassionate towards the elderly in our world, and it's good to see that somebody is passionate about curing the ails that often accompany old age.
One question that I have for Dr. West is what should the average life expectancy be for people? 100? 110?
Curing hearing and sight loss, kidney failure, liver failure are all good things that could come from recombinant DNA therapy.
But the dark side could promote supernatural human beings; turning engineered cells into engineered people. These 'superpeople' can potentially outthink, outperform and ultimately - wipe out the current natural human race that we have spent millions of years evolving into. If these cloned people reproduced with regular human beings, something called germ-line genetic modification, something terribly wrong could happen. This is one of the kind Doctor's admitted fears.
Our standard of living would become too high to sustain or even achieve. It would create many insurmountable problems the world has never known.
Tinkering with the atom in the Manhatten Project ultimately brought us terrorism as we know it today. Could those brilliant scientists not see the disaster behind the discovery?
Now our modern scientists are tinkering with the human genome project. It is mapped out and published. Scientists such as Dr. West wish to exploit this important and exciting discovery to help mankind, but we must be wary of the ever present dark side of all good creations.
Are we ready to make this scientific leap?
Read the book and ponder the answer...I have no answers at this point---the book contains arguments both ways, but leans towards the pro and dismisses the con pretty blantantly.
Nonetheless, it is a very interesting read, and contains somewhat technical ideas in it, which only encourages me to further research the topic of theraputic cloning and stem cell research.
13 of 15 people found the following review helpful.
more self promotion than the discussion of the subject matter
By W. Chen
After reading so many positive reviews, I ordered the book, and expected to learn in-depth insight into the immortality of cells.
I was disappointed. This book is more of the author's personal story of pursuing the goal of reversing aging rather than detailed look into the biological nature of aging. There are tidbits of gems here and there, but the density is low. If you are looking for a serious discussion of the subject matter, this book is not for you.
7 of 8 people found the following review helpful.
Brilliant and Passionate
By Ed Roche
Excellent reicital of one scientist's search for the means to prolong human life. I found it to be a very good introduction to concepts such as stem cells and telomerase - areas I had only vague knowledge. But the best part of the book is its description of Dr. West's passion for ending human death and mortality. Dr. West echoes many thoughts I have had myself - man does not want to die! Despite the narrow minded opposition of obsolete religious teachings, science will find the way to overcome and we will reach one of mankind most long soughts yearnings. Perhaps we will lose part of our humanity in doing so, but in my opinion it will be a transformational change that takes us to the next level of life. This book describes one possible approach on this journey.
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